Making Both Ends Meet

Hypothalamic glucose sensing: making ends meet

The neuroendocrine system governs essential survival and homeostatic functions. For example, growth is needed for development, thermoregulation maintains optimal core temperature in a changing environment, and reproduction ensures species survival. Stress and immune responses enable an organism to overcome external and internal threats while the circadian system regulates arousal and sleep such...

Making ends meet: String unification and low-energy data.

A long-standing problem in string phenomenology has been the fact that the string unification scale disagrees with the GUT scale obtained by extrapolating low-energy data within the framework of the minimal supersymmetric standard model (MSSM). In this paper we examine several effects that may modify the minimal string predictions and thereby bring string-scale unification into agreement with l...

Making Ends Meet: Reconciling Eoholism and Animal Rights Individualism

Making Ends Meet: Chemically Mediated Circularization of Recombinant Proteins

A selective N→S acyl transfer reaction facilitates semi-synthesis of the plant cyclotide kalata B1 from a linear precursor peptide of bacterial origin, through simple appendage of N-terminal cysteine and a thiol-labile C-terminal Gly-Cys motif. This constitutes the first synthesis of a ribosomally derived circular miniprotein, without recourse to protein splicing elements.

How do tumors make ends meet?

W Barbara McClintock irradiated strains of Indian corn in the early 30s, she identified ring chromosomes, which she soon realized were a special case of chromosomes broken by radiation; the broken ends sometimes fused to one another and formed a ring (1, 2). This discovery led McClintock to hypothesize the existence of a special structure at the chromosome tip that would maintain chromosome sta...